obtaining a three dimensional structure of human MGLL with the small molecule d. cocrystallizing human MGLL with the small molecule to form a crystal of MGLL c. contacting human MGLL with a small molecule that binds to human MGLL b. A method of identifying an agent that binds to human MGLL comprising the steps of: a. A computer system of claim 7, wherein the information comprises the structure coordinates of Table 5 or homologous structure coordinates comprising a root mean square deviation of non-hydrogen atoms of less than about 1.5 Å when superimposed on the non-hydrogen atom positions of the corresponding atomic coordinates of Table 5.ġ1. A computer system of claim 7, wherein the information comprises an electron density map of a crystal form comprising SEQ ID NO: 7.ġ0.
A computer system of claim 7, wherein the information comprises diffraction data obtained from a crystal comprising SEQ ID NO: 7.ĩ. a user interface to view the information.Ĩ. a database containing information on the three dimensional structure of MGLL, or a fragment or a structural motif or derivative thereof, and a ligand, wherein said ligand is a small molecule inhibitor, stored on a computer readable storage medium and, b. The crystal of claim 1 comprising a unit cell having dimensions of about a=93.95, b=128.45, c=60.6.ħ. A crystal of claim 1 comprising an atomic structure characterized by the coordinates of Table 5.Ħ. The crystal of claim 1, wherein said ligand is selected from the group consisting of the following structures:ĥ. The crystal of claim 1, wherein said crystal has a spacegroup of C222 1.Ĥ. The crystal of claim 1 wherein said fragment or derivative thereof is a peptide comprising SEQ ID NO: 7 or a peptide having at least 95% sequence identity to SEQ ID NO: 7.ģ. A crystal comprising monoacylglycerol lipase (MGLL), or a fragment, or structural motif or derivative thereof, and a ligand, wherein said ligand is a small molecule inhibitor.Ģ. MEDIUM AND CULTURE OF EMBRYONIC STEM CELLSġ. VACCINE FOR PORCINE POST-WEANING DIARRHEA CAUSED BY ENTEROTOXIGENIC ESCHERICHIA COLI PROMOTER, PROMOTER CONTROL ELEMENTS AND COMBINATIONS AND USES THEREOFĪSSAY FOR GENETIC POLYMORPHISMS USING SCATTERED LIGHT DETECTABLE LABELS Method for the biotransformation of carotenoids by means of a cytochrome p450 monooxygnase Method Of Producing Haploid And Doubled Haploid Plant Embryos, And Embryos, Plants, Progeny, Cells, Tissues And Seeds Obtainable By Method Method for controlling the yeast-to-filamentous growth transition in fungi Mobilization of Stem Cells After Trauma and Methods Therefor
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